Journal: Molecular Oncology

Article Title: Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

doi: 10.1002/1878-0261.13788

Figure Lengend Snippet: Proteomic profiling of EWS primary tumors and metastases reveals a distinct protein expression profile. (A) Example of a tumor (left) and a metastasis (right) chip from the Phospho Explorer array. Green fluorescent intensity indicative of protein expression (lighter = more expression). (B) Venn diagram indicating, from the total number of proteins present in the array (1320), which proteins were detected in each sample group. In the overlap (proteins detected in both sample groups), the list of proteins that passed the selection criteria (0.5 < FC >2; blue = tumors, red = metastases). (C) Comparison of each pair of A673 tumor‐metastasis, indicating the proteins detected in each subset and those shared. From these, the list and FC expression values are shown for those that passed selection criteria. In bold, those shared in 2/3 metastases. Red = higher expression in metastases; Blue = higher expression in tumors. Samples analyzed; n = 6. EWS, Ewing sarcoma; FC, fold change.

Article Snippet: Proteomic expression analyses were done using the Phospho Explorer Antibody Array (Full Moon Biosystems, TebuBio, Le Perray en Yvelines, France).

Techniques: Expressing, Selection, Comparison